WWE SmackDown vs. Raw 2010 (also known as WWE SmackDown vs. Raw 2010 featuring ECW) is a professional wrestling video game developed by Yuke's and published by THQ for PlayStation 2 (PS2), PlayStation 3 (PS3), PlayStation Portable (PSP), Wii, Nintendo DS, Xbox 360, and iOS. It was released worldwide in October 2009, with the PS3 and Xbox 360 versions for Japan in January 2010. TOSE oversaw the development for the Nintendo DS version, which was the last installment to be released for the handheld. 2010 was also the first installment to be released as an iPhone app, launching on App Store on December 23 the same year.

SmackDown vs. Raw 2010 is the eleventh overall installment in the video game series based on the professional wrestling promotion World Wrestling Entertainment (WWE), the successor to 2008's SmackDown vs. Raw 2009, and the sixth game under the SmackDown vs. Raw name; named after the promotion's SmackDown and Raw brands. It was also the third and final game to feature the promotion's ECW brand before its dissolution in February 2010.

The game adds several new features focused around customization, such as a Story Designer that allows players to create their own storylines, "Road to Wrestlemania", an expansion on the "Create-a-Finisher" mode to include aerial techniques. New additions exclusive to the PlayStation 3 and Xbox 360 versions are the customization of attire colors in a mode called "Superstar Threads", a revamped "Create-a-Superstar" mode, and a paint tool for creating logos to use on their created characters.