According to online reports, Rey Mysterio took a Wellness test backstage at the February 13, 2012 edition of Raw Supershow in his hometown of San Diego, California.
Rey's test came back positive for amphetamines and WWE notified Mysterio earlier this week that he wouldn’t be able to make his late-May/early-June return from knee injury because he would have to serve a 60-day Wellness Policy suspension.
Mysterio was reportedly confused about what caused the positive result and blamed it on a medication or supplement he had been taking. He denied knowingly taking any drugs that would have caused the positive test result but was unable to produce a valid prescription thus was suspended.
Source: Wrestling News World